Abstracts

Using normal fat mass to account for body size and composition

Nick HolfordNick Holford - 2016 Oral presentation

A pilot study to investigate the relationship between doxorubicin and doxorubicinol pharmacokinetics and cardiotoxicity in children and adolescents with cancer

Stefanie HennigStefanie Hennig (1), Kuhan Kunarajah (2), Ross Norris (1,3,4), Michael Lobb (3), Bruce Charles (1,3), Ross Pinkerton (5), Andrew S. Moore (2,5,6) - 2016 Poster presentation

Quantitative model diagrams (QMD): a new perspective in model evaluation

Benjamin GuiastrennecBenjamin Guiastrennec (1), Ron J. Keizer (2) and Mats O. Karlsson (1) - 2016 Poster presentation

Understanding Identifiability of random effects in mixed effects models

Leon AaronsMarc Lavielle, Leon Aarons - 2016 Poster presentation

Dose selection for rifabutin in combination with HIV-protease inhibitors

Stefanie HennigHennig S (1,2), Svensson EM (2), Niebecker R (2), Fourie B (3), Weiner MH (4), Bonora S (5), Peloquin CA (6), Gallicano K (7), Flexner C (8), Pym A (9), Vis P (10), Olliaro PL (11), McIlleron H (12), Karlsson MO (2) - 2016 Poster presentation

Using a PK/PD modeling approach to optimize the dosing regimen of secukinumab for the treatment of moderate to severe plaque psoriasis

Mick LoobyOliver Sander, Achim Guettner, Charis Papavassilis, Michael Looby - 2016 Oral presentation

Regulatory endorsed of M&S platforms: The case of Alzheimer Disease CTS

Klaus RomeroKlaus Romero (1) - 2016 Oral presentation

Understanding the influence of vitamin K on warfarin dosing requirements

Qing-Xi OoiQing-Xi Ooi (1), Daniel Wright (1), Campbell Tait (2), Geoffrey Isbister (3), Stephen Duffull (1) - 2016 Oral presentation

Prediction of fat free mass in children

Hesham Al-SallamiHesham Al-Sallami (1), Ailsa Goulding (2), Andrea Grant (3), Rachael Taylor (2), Nicholas Holford (4), Stephen B Duffull (1) - 2016 Oral presentation

Pharmacometric modelling of antimalarial drugs in development: from challenge to clinics

Nathalie GobeauNathalie Gobeau1, Leesa Wockner2, Henning Schmidt3, Jörg Möhrle1, James McCarthy2 - 2016 Oral presentation

Road to individualising tacrolimus therapy in solid organ transplant recipients

Dr Christine StaatzChristine Staatz (1) - 2016 Oral presentation

Population Pharmacokinetic Analysis of Levetiracetam in Adult Malaysian Patients with Epilepsy

Yoke-Lin LoLi-Ling Yeap (1)(2), Chong-Tin Tan (2), Kheng-Siang Lim (2), Yoke-Lin Lo (2)(3) - 2016 Poster presentation

Translation between two models; Application with integrated glucose homeostasis models

Moustafa IbrahimMoustafa M.A. Ibrahim , Anna Largajolli, Maria C. Kjellsson, , Mats O. Karlsson - 2016 Poster presentation

nlmixr: an open-source package for pharmacometric modelling in R

Rik SchoemakerRik Schoemaker (1), Yuan Xiong (2), Justin Wilkins (1), Christian Laveille (3), Wenping Wang(4) - 2016 Poster presentation

Comparison of non-compartmental analysis and non-linear mixed effects ability to determine bioequivalence in drugs with two-compartment kinetics

Jim HughesJim H Hughes (1), Richard N Upton (1), David J R Foster (1) - 2016 Poster presentation

Population modelling of functional disability in early rheumatoid arthritis treated according to a treat-to-target strategy

Jessica WojciechowskiJessica Wojciechowski (1), Nasir Wabe (2), Michael D Wiese (2), Susanna M Proudman (3,4), David J R Foster (1), Richard N Upton (1) - 2016 Poster presentation

Bayesian forecasting versus clinical practice for intravenous busulfan dose adjustment in paediatric stem cell transplantations

Lachlan PatersonMr Lachlan G Paterson (1), Ms Rachael Lawson (2), Dr Stefanie Hennig (1) - 2016 Poster presentation

NextDose: a web-based collaborative tool for target concentration intervention

Dr Sam HolfordSam Holford, NHG Holford - 2016 Oral presentation

A viral kinetic model for severe human cytomegalovirus infections in immunocompromised paediatric patients

Mr Ben MargettsMr Ben Margetts (1,2,3), Professor Judith Breuer (2,3), Professor Nigel Klein (1,2,3), Dr Joseph Standing (1,2,3) - 2016 Poster presentation

How Pharmacometrics can improve the power of pharmacogenetic studies

Julie BertrandJulie Bertrand (1,2), Maria de Iorio (3), David Balding (2) - 2016 Poster presentation

Advanced methods for dose finding during drug development: Summary of the EMA /EFPIA workshop on dose finding (London 4-5 December 2014)

Flora Musuamba TshinanuFlora Musuamba Tshinanu - 2016 Oral presentation

Development of a Biomarker-based Prediction Model of Disease Progression during Chemotherapy in Young Adolescents

Young A HeoYoung A Heo (1, 2), Kyungsoo Park (1) - 2016 Poster presentation

Mechanistic model for calcium treatment effect in calcium-parathyroid hormone homeostasis after thyroidectomy in Koreans.

Mijeong SonMijeong Son(1),(2), Yukyung Kim(1),(2), Dongwoo Chae(1),(2), Jinju Guk(1),(2), Young-A Heo(1),(2) and Kyungsoo Park(1) - 2016 Poster presentation

Imputation methods to correct overestimated shape parameter of Weibull hazard function in time-to-event modeling

Dong-Seok YimDong-Seok Yim - 2016 Poster presentation

Internal Deterministic Identifiability

Vijay Kumar SiripuramVijay Kumar Siripuram(1), Daniel F.B. Wright(1), Murray L. Barclay(2), Stephen B. Duffull(1) - 2016 Poster presentation

Simulation Analysis to Explore the Optimal Combination of Pregabalin and Duloxetine

Ah Ra KohAh Ra Koh(1), Kyun-Seop Bae(1), Seong Bok Jang(2), Woon Sook Na(2), Su Yoon Nam(2), Hyeong Seok Lim(1) - 2016 Poster presentation

Pharmacokinetic and Pharmacodynamic Analysis of GCC-4401C, a Novel Direct Factor Xa Inhibitor, in Healthy Volunteers

Hyeong-Seok LimHee Youn Choi(1), Soongyu Choi(2), Yo Han Kim(1), Hyeong-Seok Lim(1) - 2016 Poster presentation

Physiologically Based Pharmacokinetic Models for Trastuzumab Using Serial Concentrations Meausred By Optical Imaging in Mouse

Hyeong-Seok LimDong-Jun Bae(2), Sang-Yeob Kim(2,3), Ara Koh(1), Kwan Cheol Pak(1), Hyeong-Seok Lim(1) - 2016 Poster presentation

Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis of A Novel Donepezil Patch Formulation

Hyeong-Seok LimHee Youn Choi(1), Yo Han Kim(1), Donghyun Hong(2), Seong Su Kim(2), Young Kweon Choi(2), Kyun-Seop Bae(1), Hyeong-Seok Lim(1) - 2016 Poster presentation

Population Plasma and Urine Pharmacokinetics of Ivabradine and its Active Metabolite in Korean Healthy Volunteers

Hyeong-Seok LimHee Youn Choi(1), Kyun-Seop Bae(1), Sang-Heon Cho(2), Jong-Lyul Ghim(3), Sangmin Choe(4),Jin Ah Jung(3), Hyeong-Seok Lim(1) - 2016 Poster presentation

A simulation study to evaluate treatment effect of tamoxifen by CYP2D6 genotypes compared with AIs

Gwan Cheol ParkGwan Cheol Park (1), Jin-A Jung (1), Ara Koh (1), Kyun-Seop Bae (1), Hyeong-Seok Lim (1) - 2016 Poster presentation

Pharmacokinetic Modeling and Simulation Analysis of LCB01-0371, a New Oxazolidinone Antibiotic Under Clinical Development

Hyeong-Seok LimYo Han Kim (1,2), Hee Youn Choi (1,2), Yong Zu Kim (3), Young Lag Cho (3), Hee Sook Nam (3), Kyun-Seop Bae (1,2), Hyeong-Seok Lim (1,2) - 2016 Poster presentation

Population Pharmacokinetics of Artesunate and Dihydroartemisinin in Patients with Sensitive and Resistant Malaria Infection

Thanaporn WattanakulThanaporn Wattanakul1,2, Debashish Das1,3, Rupam Tripura1, Aung Pyae Phyo4, Khin Maung Lwin4, Poravuth Yi5, Nicholas P. J. Day1,2, Duong Socheat5, Chea Nguon5, Nicholas J. White1,2, François Nosten1,2,4, Arjen M. Dondorp1,2, Joel Tarning1,2,3 - 2016 Poster presentation

What purpose is the DDMoRe library serving?

Iñaki F. TrocónizZinnia P Parra-Guillen (1,2) and Iñaki F. Trocóniz (1) - 2016 Oral presentation

When statistics and pharmacometrics join forces for advanced quantitative drug development: A case study

Emmanuel ZuberAngelika Caputo (1), Cornelia Dunger-Baldauf (1), Ines Paule (1), Amy Racine (1), Yuan Xiong (2), Emmanuel Zuber (1) - 2016 Oral presentation

Model-Based Meta-Analysis on the Efficacy of Pharmacological Treatments for Idiopathic Pulmonary Fibrosis

Phyllis ChanPhyllis Chan(1), Leon Bax(2), Chunlin Chen(1), Nancy Zhang(2), Shu-Pang Huang(1), Holly Soares(1), Glenn Rosen(1), and Malaz AbuTarif(1) - 2016 Poster presentation

A population model for respiratory syncytial virus (RSV) kinetics using transit compartments based on human challenge data

Julia KorellJulia Korell (1), Bruce Green (1), Dymphy Huntjens (2) - 2016 Oral presentation

Faster ADVAN-style analytical solutions for simulations from common pharmacokinetic models

Ahmad Y AbuhelwaAhmad Y Abuhelwa (1), David J.R Foster (1), Richard N Upton (1) - 2016 Poster presentation

A Quantitative Systems Pharmacology Model to Predict the Effects of Warfarin, Rivaroxaban and Enoxaparin on the Human Coagulation Network

Mirjam N. TrameSonja Hartmann (1), Konstantinos Biliouris (1), Lawrence J Lesko (1), Ulrike Nowak-Göttl (2), Mirjam N Trame (1) - 2016 Poster presentation

Evaluation of Covariate Effect Size based on Parameter Variability

Takayuki KatsubeTakayuki Katsube, Toru Ishibashi, Toshihiro Wajima - 2016 Poster presentation

Evaluation of linezolid-induced thrombocytopenia based on hospital pharmacometrics

Yasuhiro TsujiYasuhiro Tsuji (1), Nick Holford (2) - 2016 Oral presentation

How can users benefit from the DDMoRe common language standard and interoperability framework?

Phylinda LS ChanPhylinda LS Chan (1), Mike K Smith (1), Peter A Milligan (1), Lutz O Harnisch (1) on behalf of the DDMoRe Consortium - 2016 Oral presentation

What advanced methods and algorithms are promoted through DDMoRe?

Andrew C. HookerAndrew C. Hooker - 2016 Oral presentation

Pseudomonas aeruginosa eradication therapy predicts the hazard of having Aspergillus Fumigatus positive culture in early life of children with CF

Sabariah Noor HarunSabariah Noor Harun (1,2), Claire Wainwright (3,4), Nick Holford (1,5), Stefanie Hennig (1) - 2016 Poster presentation

An optimal sampling schedule for neonates, infants & children receiving cefazolin +/- vancomycin for cardiopulmonary bypass

Jacqueline A HannamJ. A. Hannam (1), B. J. Anderson (1), N. H. G. Holford (2). - 2016 Poster presentation

Would a certification process for models published on the DDMoRe repository serve the modelling community?

Siv JonssonSiv Jonsson - 2016 Oral presentation

Population pharmacokinetic model of pegylated interferon alfa-2a in healthy Korean male subjects

Yun Seob JungYun Seob Jung (1), Dong woo Chae (1), Kyungsoo Park (2) - 2016 Poster presentation

Evaluation of intraocular penetration of levofloxacin after administration drop solution by high performance liquid chromatography and comparison with ciprofloxacin

Amir HeydariAmir Heydari(1), Mahsa Hasanzadeh(2), Vafa Samarai(3) - 2016 Poster presentation

Application of continuous-time Marcov exposure-response model to sIGA. Nemolizumab case

Tomohisa SaitoTomohisa Saito, Satofumi Iida, Kimio Terao - 2016 Poster presentation

Population pharmacokinetic model of gentamicin in paediatric oncology patients.

Carolina Llanos-PaezCarolina Llanos-Paez (1), Christine Staatz (1), Rachael Lawson (2), Stefanie Hennig (1) - 2016 Poster presentation

Examining the predictive performance of different equations to estimate glomerular filtration rate in paediatric oncology patients.

Carolina Llanos-PaezCarolina Llanos-Paez (1), Christine Staatz (1), Rachael Lawson (2), Stefanie Hennig (1) - 2016 Poster presentation

Population of Pharmacokinetics of Tanezumab in Pateints with Chronic Low Back Pain

Rujia XieRujia Xie (1), Guangli Ma (1), Scott Marshall (2), Rosalin Arends (3) - 2016 Poster presentation

Tofacitinib Pharmacokinetics in Moderate-to-Severe Crohn’s Disease Patients in Phase 2 Induction and Maintenance Studies

Chenhui DengChenhui Deng (1), Rujia Xie (1), Steven W Martin (2), Gary Chan (3), Michele Moscariello (4), Wojciech Niezychowski (4), Eric Maller (4), Arnab Mukherjee (4) - 2016 Poster presentation

Application of a multi-criteria decision analysis model in the dose selection of combination therapy for overactive bladder

Mats O. MagnussonMats O. Magnusson - 2016 Oral presentation

The population pharmacokinetics of OZ439 in healthy volunteers and patients with falciparum and vivax malaria

Piyanan (Jill) AssawasuwannakitPiyanan Assawasuwannakit (1), Aung Pyae Phyo (1,2,3), Podjanee Jittamala (4), François Nosten (1,2,3), Sasithon Pukrittayakamee (5), Mallika Imwong (6), Nicholas White (1,3), Stephan Duparc (7), Fiona Macintyre (7), Mark Baker (7), Jörg Möhrle (7), Paul van Giersbergen (8), Berber Snoeijer (9), Britta Siethoff (10), Joel Tarning (1,3) - 2016 Poster presentation

Quantitative Review and Meta-models of Gastrointestinal pH to Help Inform Mechanistic Oral Absorption Models

Ahmad Y AbuhelwaAhmad Y Abuhelwa (1), David J.R Foster (1), Richard N Upton (1) - 2016 Poster presentation

Quantitative Review and Meta-models of Gastrointestinal Transit Times to Help Inform Mechanistic Oral Absorption Models

Ahmad Y AbuhelwaAhmad Y Abuhelwa (1), David J.R Foster (1), Richard N Upton (1) - 2016 Poster presentation

Mechanism-based modelling to assess suppression of bacterial resistance by high intensity, short duration tobramycin exposure

Vanessa E ReesVanessa E Rees (1), Jürgen B Bulitta (2), Antonio Oliver (3), Fritz Sörgel (4,5), Brian Tsuji (6), Craig Rayner (1,7), Roger L Nation (1), Cornelia B Landersdorfer (1,6) - 2016 Poster presentation

A Framework for quantifying the influence of adherence and dose individualization

Piyanan (Jill) AssawasuwannakitPiyanan Assawasuwannakit (1,2), Rhiannon Braund (1), Stephen B Duffull (1) - 2016 Oral presentation

Amikacin pharmacokinetics in Pediatric patients with burn injuries compared to those with oncology conditions

Catherine MT SherwinXiaoxi Liu(1); Anne Smits(2,3); Tian Yu(1); Stephanie Wead(4); Alice Neely(5); Richard Kagan(5,6); Daniel Healy(5,7); Karel Allegaert(8,9); Catherine M. Sherwin(1) - 2016 Poster presentation

Placebo effect in overactive bladder clinical studies: longitudinal model-based meta-analysis of micturitions

Chihiro HasegawaChihiro Hasegawa (1), Tomoya Ohno (1) - 2016 Poster presentation

Big world challenges for pharmacometrics

Mats O KarlssonMats O Karlsson (1) - 2016 Oral presentation

Application of a quantitative systems pharmacology (QSP) model to evaluate xCT inhibition as a target for central nervous system diseases.

Mike ReedCM Friedrich1, CM Witt1, MM Pryor1, T Rooney2, A Genevois-Borella2, MC Obinu2, A Guerreiro2, J Konop2, MJ Reed1, Z Bocskei2 - 2016 Poster presentation

Challenges in treating infectious disease – linking epidemiology with pharmacometrics

Steven E. KernSteven E. Kern - 2016 Oral presentation

Modeling and simulation with evolving cancer therapies: combinations, cancer immunotherapy, and more

Jin JinJin Jin - 2016 Oral presentation

The importance of body size for bridging studies

Masato KanekoTakahiko Tanigawa (1), Masato Kaneko (1), Ryosei Kawai (1) - 2016 Oral presentation

Population pharmacokinetics and pharmacodynamics of an oral glucagon receptor antagonist (LY2409021) and implications of patient dropout

Emmanuel ChigutsaEmmanuel Chigutsa (1), Timothy Waterhouse (1), Cheng Cai Tang (2), Michael Heathman (1), Parag Garhyan (1) - 2016 Oral presentation

A simple mechanistic pharmacometric model for HIV in children and adults

Joe StandingRollo Hoare (1,2), Eva Germovsek (1), Mario Cortina-Borja (1), Nigel Klein (1,2,3), Robin Callard (1,2), Joe Standing (1,2,3) - 2016 Oral presentation

Why MIC is poison for the mind

Hartmut DerendorfHartmut Derendorf - 2016 Oral presentation

Assessment of pharmacometric and statistical analysis methods in dose-finding trial design: application in diabetes drug development

Timothy WaterhouseTimothy Waterhouse (1), Xiaosu Ma (1), Jenny Chien (1), Cory Heilmann (1), David Manner (1) - 2016 Oral presentation

Recommended doses of Levobupivacaine for TAP Blocks: Development of a pharmacokinetic model and estimation of the risk of symptoms of local anesthetic systemic toxicity

Luis CortinezLuis Cortinez - 2016 Oral presentation

Developing next-generation malaria medicines to address drug resistance and increase the operational feasibility of malaria elimination efforts

David ReddyDavid Reddy - 2016 Oral presentation

Pharmacometric modelling of antimalarial drugs in development

Joel TarningJoel Tarning (1,2), Tran Tinh Hien (3), Nicholas White (1,2), Nguyen Thanh Thuy Nhien (3), Nhu Thi Hoa(3), Phung Duc Thuan(3), Francois Nosten (1,2,4), Baldur Magnusson (5), Jay Prakash Jain (6), Micha Levi (7), Kamal Hamed (7) - 2016 Oral presentation

Introduction to human challenge models for respiratory viruses and the application of quantitative pharmacology to enhance drug development

Craig R. RaynerCraig R. Rayner - 2016 Oral presentation

Challenges and pitfalls of building models for Flu/RSV and respiratory viruses

Kashyap PatelKashyap Patel (1), Patrick Smith (2), Keith Nieforth (2), Carl Kirkpatrick (1) - 2016 Oral presentation

Modeling tumor size and survival in patients with metastatic gastric cancer

Dong Woo ChaeDong Woo Chae (1), Joo Hoon Kim (2,3), Hyun Cheol Chung (2,3), Sung Young Rha (2,3), Kyung Soo Park (1) - 2016 Oral presentation

Pharmacometricians and statisticians in drug development: can’t we all just get along?

Stacey TannenbaumStacey Tannenbaum (1), Kenneth Kowalsi (2) - 2016 Oral presentation

Pharmacometrics, biostatistics and computational biology postgraduate training: how can we integrate courses?

Julie SimpsonJulie Simpson - 2016 Oral presentation

Application of a multi-criteria decision analysis model in the dose selection of combination therapy for overactive bladder

Mats O. MagnussonMats O. Magnusson - 2016 Oral presentation

Bench-to-bedside translation of antibody drug conjugates (ADCs) using a multiscale mechanistic PK/PD model

Dhaval ShahDhaval Shah - 2016 Oral presentation

Optimization of trial design and dose selection based on the quantitative assessment of the efficacy of TAK-385, an investigational, oral GnRH antagonist, in patients with prostate cancer

Nelleke SnelderPeter Vis (1), Nelleke Snelder (1), Maurice Ahsman (1), David MacLean (2), Helene Faessel (2) - 2016 Oral presentation

An analysis of patient-reported outcomes (PRO) in breast cancer patients through item-response theory (IRT) pharmacometric modeling

Emilie SchindlerEmilie Schindler (1), Bei Wang (2), Bert L. Lum (2), Sandhya Girish (2), Jin Y. Jin (2), Lena E. Friberg (1), Mats O. Karlsson (1) - 2016 Oral presentation