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Author: Koh Ah Ra

2016

Population Plasma and Urine Pharmacokinetics of Ivabradine and its Active Metabolite in Korean Healthy Volunteers

Posted on August 19, 2016 by Koh Ah Ra

Aims: Ivabradine, a selective inhibitor of the pacemaker current (If), is used for heart failure and coronary heart disease, and mainly metabolized to S18982 (1...

2016

Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis of A Novel Donepezil Patch Formulation

Posted on August 19, 2016 by Koh Ah Ra

Aims: Donepezil is a well-known reversible noncompetitive acetylcholinesterase inhibitor for the symptomatic treatment of Alzheimer’s disease (AD). The purpose ...

2016

Physiologically Based Pharmacokinetic Models for Trastuzumab Using Serial Concentrations Meausred By Optical Imaging in Mouse

Posted on August 19, 2016 by Koh Ah Ra

Aims: Trastuzumab is a monoclonal antibody that is mainly used to treat breast cancer and exerts its therapeutic effect by inhibiting the HER2/neu receptor. The...

2016

Pharmacokinetic and Pharmacodynamic Analysis of GCC-4401C, a Novel Direct Factor Xa Inhibitor, in Healthy Volunteers

Posted on August 19, 2016 by Koh Ah Ra

Aims: GCC-4401C, an orally active direct factor Xa inhibitor which is similar to rivaroxaban, is currently under development for venous thromboembolic disease. ...

2016

Simulation Analysis to Explore the Optimal Combination of Pregabalin and Duloxetine

Posted on August 19, 2016 by Koh Ah Ra

Aims: Pregabalin, an anticonvulsant drug and duloxetine, a selective serotonin-norepinephrine reuptake inhibitor (SNRI) are used for pain relief. The purpose of...

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